12:00-17:00

Registration

12:30-15:30

Council of Physiology Professors

12:30-15:30

FEPS Council

13:30-15:30

Young Physiologists meeting

15:30-16:00

Opening Ceremony     [Aula Magna]

16:00-17:00

Opening Lecture     [Aula Magna]

Susan Wray (Liverpool, United Kingdom)

The science and future of the uterus

17:30-18:30

Welcome cocktail     [Chiostro di San Faustino]

19:00-20:00

Piano Concert     [Chiesa di San Giuseppe]

08:30-10:00

Parallel Symposia

Special event on the occasion of the 150th anniversary of the Physiological Society
Building on the breakthroughs of Dr Florence Buchanan: advancing the frontiers of muscle physiology (Sponsored by The Physiological Society)     [Aula Magna]
Chairs: Damian Bailey (Cardiff, United Kingdom) & Sarah Bundock (London, United Kingdom)

Damian Bailey (Cardiff, United Kingdom)

From reflex arcs to missing faces: the science and legacy of Dr Florence Buchanan

Colleen Deane (Southamption, United Kingdom)

Muscle health across the lifecourse: nutrition, exercise and the utility of omics

Jakob Škarabot (Loughborough, United Kingdom)

The neural-contractile nexus in healthy ageing

Grith Stougaard Højfeldt (Copenhagen, Denmark)

Regulation of human skeletal muscle following injury: dual-omics and protein turnover insights

Neurocardiac cross-talk in inherited and acquired cardiac disease     [Auditorium A1]
Chairs: Molly O'Reilly (Amsterdam, The Netherlands) & Alain Lacampagne (Montpellier, France)

Tania Zaglia (Padua, Italy)

Cardiac sympathetic neurons are additional cells affected in genetically determined arrhythmogenic cardiomyopathy

David Paterson (Oxford, United Kingdom)

Next generation neuromodulation to prevent hypertension-induced ventricular arrhythmias

Molly O'Reilly (Amsterdam, The Netherlands)

Redefining catecholaminergic polymorphic ventricular tachycardia (CPVT) as a neurocardiac condition

Christopher O’Shea (Birmingham, United Kingdom)

TBA

Understanding how complex cognition transforms sensory information: neural computations from single neurons to cell assembly in the frontal cortex     [Auditorium B1]
Chairs: Francesco Ceccarelli (Rome, Italy) & Aldo Genovesio (Novara, Italy)

Emiliano Brunamonti (Rome, Italy)

Neural computations underlying decision-making supported by mental schemas

Aldo Genovesio (Novara, Italy)

Reviving Hebb’s theory: from single neurons to neuronal assemblies as units of information processing

Surabhi Ramawat (Lyon, France)

Learning to choose by rank-order: reconfiguration of stimulus encoding in primate prefrontal cortex after learning during a transitive inference task

Sofia Raglio (Paris, France)

From sequence processing to abstract cognition: transitive inference paradigm in artificial and cortical networks

How the retina computes: circuit motifs, state modulation, and timing strategies for the brain     [Auditorium C1]
Chairs: Stefano Di Marco (Genoa, Italy) & Serena Riccitelli (Genoa, Italy)

Olivier Marre (Paris, France)

VIP+ amacrine cells synchronize retinal activity

Michal Rivlin (Rehovot, Israel)

Direction selectivity and its role in encoding visual cues to self-motion: from the retina to the visual thalamus

Serena Riccitelli (Genoa, Italy)

Top-down modulation of the retinal code via histaminergic neurons of the hypothalamus

Annalisa Bucci (Zürich, Basel, Switzerland)

Synchronization of visual signals in the human fovea: insights from electrophysiological recordings and beyond.

10:00-11:00

Parallel Oral Communications

11:00-11:30

Coffee break

11:30-12:30

FEPS Lecture     [Aula Magna]

Alice Assinger (Vienna, Austria)

Liver regeneration: the role of platelets and the immune system

12:30-14:30

Poster Session and Lunch

14:30-15:30

Parallel Oral Communications

15:30-16:00

Coffee break

16:00-17:30

Parallel Symposia

Modeling human neurodevelopment: 2D and 3D systems in physiological and pathophysiological conditions     [Aula Magna]
Chairs: Bruno Sterlini (Genoa, Italy) & Bernadette Basilico (Rome, Italy)

Nael Nadif Kasri (Nijmegen, The Netherlands)

Multimodal mapping of neuronal network activity and transcriptomic identifies convergent and divergent neurons in neurodevelopmental disorders

Orly Reiner (Rehovot, Israel)

Brain Organoids as a Window into Human Neurodevelopmental Malformations: Phenotypes, Mechanisms, Rescue

Davide Aprile (Milan, Italy)

Cerebellar organoids for neurodevelopmental disease modelling: from gene regualation to assembloids and circuits

Bernadette Basilico (Rome, Italy)

Dissecting Patient-Specific Mechanisms in SYNGAP1 Syndrome Using Human In Vitro Models

Blood-brain barrier permeability in health and disease: mechanisms and modulation     [Auditorium A1]
Chairs: Valentina Castagnola (Pisa, Italy) & Luca Maragliano (Ancona, Italy)

Giuseppe Battaglia (Barcelona, Spain)

Macromolecular transport at the blood-brain barrier: mechanisms, dysfunctions, and therapeutic opportunities.

Matthew Campbell (Dublin, Ireland)

Regulation of claudin-5 at the blood-brain barrier in health and disease

Martina Trevisani (Helsinki, Finland)

Targeting tight junctions: blood-brain barrier modulation through claudin-5-binding peptides

Arianna Benedetti (Genoa, Italy)

Oxytocin seals the blood-brain barrier, improving 22q11.2 deletion syndrome trajectories

Novelty in phosphate homeostasis
(Sponsored by the French Society of Physiology and Integrative Biology, SPBI)     [Auditorium B1]
Chairs: Sandrine Lemoine (Lyon, France) & Emmanuel Letavernier (Paris, France)

Sandrine Lemoine (Lyon, France)

Renal phenotype in X linked ricket patients

Guillaume Courbon (Saint Etienne, France)

Phosphate homeostasis, erythropoiesis and iron metabolism

Paola Ciceri (Milan, Italy)

Phosphate-Induced Endothelial Calcification: Cellular and Molecular Mechanisms

Caroline Halimi (Paris, France)

Differential Calcium-Sensing Receptor Sensitivity in Primary Hyperparathyroidism?

Physiology for space: what can we learn from animal and human models     [Auditorium C1]
Chairs: Matteo Cerri (Bologna, Italy) & Arianna Mazzoli (Naples, Italy)

Arianna Mazzoli (Naples, Italy)

Metabolic Health and Probiotic Modulation: Insights from Animal Models 

Marco Narici (Padua, Italy)

Neuromuscular impairment in simulated hypogravity 

Emiliana Piscitiello (Darmstadt, Germany)

Hypometabolism as a countermeasure to space radiation

Maksymilian Aleksander Brzezicki (Oxford, United Kingdom)

Central Nervous System Adaptation to Spaceflight: Mechanisms of Plasticity and Neurophysiological Monitoring

17:30-18:30

SIF Ruzzier Lecture     [Aula Magna]

Egidio D’Angelo (Pavia, Italy)

Multiscale brain models and digital twins

08:30-10:00

Parallel Symposia

Beyond small cohorts: from extreme and space physiology to integrated, tailored human research (Sponsored by Experimental Physiology)     [Aula Magna]
Chair: Irene Di Giulio (London, United Kingdom)

Alexander Stahn (Berlin, Germany)

Brain and Behavioral Adaptations to Extreme Environments: Translational Insights from Space Research

Antoine Collet (Mons, Belgium)

Cardiovascular Adaptations to Microgravity and Advanced Cardiovascular Monitoring Technologies

Siobhan Crosby (Southampton, United Kingdom)

Exploring the complexities of adaptation to extreme environments through integrated phenotyping analysis

Dominik Pesta (Cologne, Germany)

Why Muscle Fails Without Load: Translational Insights from Bed Rest to Metabolic Disease

Adaptive mechanisms and metabolic changes of non-neuronal cells in the central and peripheral nervous system     [Auditorium A1]
Chair: Nina Vardjan (Ljubljana, Slovenia)

Nicole Scholz (Leipzig, Germany)

Split decisions at neuroglial junctions: how adhesion GPCRs shape cell interactions

Nunzio Vicario (Catania, Italy)

Neuroglial intercellular communication and redox dysregulation in chronic neuropathic pain

Nina Vardjan (Ljubljana, Slovenia)

Reversing age-related motor decline through neuromodulatory calcium signals

Valerio Magnaghi (Milan, Italy)

Shaping the inflammatory cells in Schwann cell-related tumors of the peripheral nervous system 

The interplay of synaptic plasticity and oscillations in the cerebellar circuit     [Auditorium B1]
Chairs: Francesca Prestori (Pavia, Italy) & Chris I. De Zeeuw (Rotterdam, The Netherlands)

Chris I. De Zeeuw (Rotterdam, The Netherlands)

Oscillations in the Olivocerebellar System

Daniela Popa (Paris, France)

Cerebellum in defensive behaviors

Eleonora Pali (Pavia, Italy)

Dendritic processing integrates STDP on the theta band in cerebellar Golgi cells

Lucas Rudelt (Göttingen, Germany)

Dendritic predictive learning in cerebellum-like circuits

Environmental and molecular stressors regulating placental function and feto–maternal communication     [Auditorium C1]
Chairs: Leonardo Ermini (Siena, Italy) & Marco Fiocchetti (Rome, Italy)

Jorge Lopez Tello (Madrid, Spain)

Placental hormones and bacteria: partners in crime in the regulation of fetal growth

Elisa Magistrati (Basel, Switzerland)

Decoding how maternal signals regulate trophoblast invasion during human placental development using a high-content imaging screen

Leonardo Ermini (Siena, Italy)

Placental Extracellular Vesicles as Mediators of Materno–Fetal Signaling in Health and Disease

Beatrice Tranquilli (Rome, Italy)

Modulation of Maternal-Fetal Interface: In vitro evidence of pollutant-driven changes in placental-neuron communication

10:00-11:00

Parallel Oral Communications

11:00-11:30

Coffee break

11:30-12:30

SIF Lecture     [Aula Magna]

Silvano Sozzani (Rome, Italy)

Defining the boundary between immune system physiology and pathology

12:30-14:30

Poster Session and Lunch

14:30-15:30

Parallel Oral Communications

15:30-16:00

Coffee break

16:00-17:30

Parallel Symposia

Teaching Physiology in medical schools (Sponsored by the University of Brescia)     [Aula Magna]
Chair: Skadi Spindler (Amsterdam, The Netherlands)

Mathieu Nendaz (Genève, Switzerland)

Integrating Physiology teaching in a problem-based learning curriculum of medical training

Dario Torre (Turin, Italy)

Innovations in Physiology teaching and assessment in the Italian medical education system

Fiorenzo Conti (Ancona, Italy)

What, if Anything, is a Textbook of Physiology in the Digital Era (and How to Make it)

Skadi Spindler (Amsterdam, The Netherlands)

Enhancing clinical reasoning in Physiology through branching-scenario films

Multiscale modelling of brain dynamics: toward brain digital twins     [Auditorium A1]
Chairs: Fulvia Palesi (Pavia, Italy) & Claudia Casellato (Pavia, Italy)

Jan Paul Triebkorn (Marseille, France)

The Virtual (mouse) brain as instrument for understanding the physiopathological brain dynamics 

Jonathan Mapelli (Modena, Italy)

Integrating cellular level models into whole brain simulators 

Marialaura De Grazia (Pavia, Italy)

Physiopathological spiking cerebellar circuits into fMRI-based optimized virtual mouse brain dynamics 

Claudia Angela Michela Gandini Wheeler-Kingshott (London, United Kingdom)

The role of the cerebellum in brain digital twins

Multimodal Structural and Biochemical Dissection of Striated Muscle Regulation     [Auditorium B1]
Chairs: Bert Blaauw (Padua, Italy) & Luca Fusi (London, United Kingdom)

Luca Fusi (London, United Kingdom)

Sub-sarcomeric regulation of thin and thick filaments in myofibrils isolated from striated muscle

Ilaria Morotti (Florence, Italy)

Dual filament regulation of cardiac output investigated with X-ray diffraction

Leonardo Nogara (Padua, Italy)

The thin line between biochemistry and structure where myosin super relaxed state lies

Leonardo Sacconi (Florence, Italy)

Probing relaxed myosin states in hypertrophic cardiomyopathy by second-harmonic generation microscopy

Prediction and action control in adaptive behavior: a multilevel framework in a distributed network     [Auditorium C1]
Chairs: Pierpaolo Pani (Rome, Italy) & Yuki Kikuchi (Newcastle, United Kingdom)

Valentina Giuffrida (Newcastle Upon Tyne, United Kingdom)

Neural Representations of Predictive Information Processing and Adaptive Motor Control

Md. Tanbeer Haque (Rome, Italy)

Salience and Attentional Modulation of Response Control

Silvia Picazio (Rome, Italy)

Cerebellar Contribution to Inhibitory Control of Action and Thought Through Non-Invasive Brain Stiumulation

Gioele Gavazzi (Florence, Italy)

From Proactive to Reactive Control: Prefrontal Functional Gradients as a Function of Inhibitory Demand

17:30-18:30

FEPS Lecture     [Aula Magna]

Pieter Roelfsema (Amsterdam, The Netherlands)

Visual perception, visual consciousness and restoring it in blindness

19:45-20:30

Dinner speech and aperitif     [Museo Auto Storiche Brescia]

Luca Zampaglione (Tallinn, Estonia)

How cyber security can be dealt in multinational critical infrastructures

20:30

Social dinner     [Museo Auto Storiche Brescia]

08:30-10:00

Parallel Symposia

Novel approaches to understanding renal function using cutting edge metabolomics     [Aula Magna]
Chairs: Oleg Palygin (Charleston, SC, USA) & Arianna Carolina Rosa (Turin, Italy)

Markus Rinschen (Aarhus, Denmark)

Novel approaches to study metabolic communication of the kidney

Jeremy Prokop (Grand Rapids, MI, USA)

Finding Convergence in the data and omics of Renal Genetics

Christine Klemens (Tampa, FL, USA)

Amino acid metabolism in renal cysts

Daria Ilatovskaya (Augusta, GA, USA)

Sex differences in human renal metabolomics

A journey through the sensory system: from physiology to dysregulation in neurodevelopmental disorders     [Auditorium A1]
Chairs: Caterina Michetti (Genoa, Italy) & Leena E Williams (Edinburgh, United Kingdom)

Kengo Takahashi (Amsterdam, The Netherlands)

Feeling the void: inactivation-mediated investigation of the neuronal mechanisms of visual perception

Georgina Mills (London, United Kingdom)

Sensory dysfunction in epileptic encephalopathies

Leena E Williams (Edinburgh, United Kingdom)

Sense & Sensibility in Fragile X Syndrome

Lorenzo Ciano (Genoa, Italy)

Deregulation of multisensory integration during development in a mouse model of neurodevelopmental disorders

From abysses to space: how the human body copes with environmental stress     [Auditorium B1]
Chairs: Carlo Capelli (Milan, Italy) & Alex Buoite Stella (Trieste, Italy)

Frédéric Lemaître (Nancy, France)

Breath-hold diving: an economic physiological model

Paola Zamparo (Verona, Italy)

Environmental Stress at the Water Surface

Giovanni Vinetti (Bolzano/Bozen, Italy)

Raising the ceiling in high altitude adaptation

Riccardo Sorrentino (Ljubljana, Slovenia)

From Deconditioning to Prevention: Physiological Challenges of Microgravity and Countermeasure Development

The molecular architecture of the epileptic brain: new pathophysiological insights     [Auditorium C1]
Chair: Mattia Lorenzo DiFrancesco (Genoa, Italy)

Massimo Mantegazza (Valbonne-Sophia Antipolis, Nice, France)

Mechanisms of SCN1A/NaV1.1 sodium channel dysfunctions in epilepsy: Dravet syndrome and beyond.

Amanda Almacellas Barbanoj (London, United Kingdom)

Malformations of cortical development, epilepsy and co-morbidities.

Annamaria Vezzani (Milan, Italy)

Cellular and molecular inflammatory mechanisms involved in the development of epilepsy and pharmacoresistance

Alberto Sánchez-Aguilera López (Madrid, Spain)

Hippocampal and cortical rhythmpathies in experimental models of brain metastasis

10:00-11:00

Awards Ceremony

11:00-11:30

Coffee break

11:30-12:30

SIF Herlitzka Lecture     [Aula Magna]

Carlo Reggiani (Padua, Italy)

In the world of skeletal muscle fibers: new insights from omics investigations

12:30-14:30

Poster Session and Lunch

14:30-15:30

pH Lecture      [Aula Magna]

Hannah Monyer (Heidelberg, Germany)

Space cognition, from Kant to contemporary neuroscience

15:30-16:00

Coffee break

16:00-19:00

SIF Assembly